Sorting Nexin 1 antibody
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- Target See all Sorting Nexin 1 (SNX1) Antibodies
- Sorting Nexin 1 (SNX1)
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Reactivity
- Human, Rat, Mouse
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Host
- Rabbit
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Clonality
- Monoclonal
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Conjugate
- This Sorting Nexin 1 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)
- Cross-Reactivity
- Human, Mouse, Rat
- Purification
- Purified by Protein A.
- Immunogen
- Recombinant protein within human SNX1 aa 50-250.
- Clone
- 4C2
- Isotype
- IgG
- Top Product
- Discover our top product SNX1 Primary Antibody
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- Application Notes
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WB 1:300-5000
FCM 1:20-100
IHC-P 1:200-400
IF(IHC-P) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C for 12 months.
- Expiry Date
- 12 months
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- Target
- Sorting Nexin 1 (SNX1)
- Alternative Name
- SNX1 (SNX1 Products)
- Synonyms
- d254 antibody, sb:cb923 antibody, snx1 antibody, wu:fb40c08 antibody, wu:fj65g09 antibody, MGC82200 antibody, SNX1 antibody, HsT17379 antibody, VPS5 antibody, ARABIDOPSIS THALIANA SORTING NEXIN 1 antibody, ATSNX1 antibody, K16F4.11 antibody, K16F4_11 antibody, sorting nexin 1 antibody, sorting nexin 1a antibody, sorting nexin 1 L homeolog antibody, sorting nexin 1 antibody, sorting nexin-1 antibody, snx1a antibody, snx1.L antibody, SNX1 antibody, snx1 antibody, LOC100380673 antibody, Snx1 antibody
- Background
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Synonyms: Sorting nexin-1, SNX1, VPS5, HsT17379
Background: Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts in part as a component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity. Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptors (IGF2R, M6PR and SORT1) and Shiginella dysenteria toxin stxB. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi. Involvement in retromer-independent endocytic trafficking of P2RY1 and lysosomal degradation of protease-activated receptor-1/F2R. Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation, the function is dependent on GEF activity of KALRN. Required for endocytosis of DRD5 upon agonist stimulation but not for basal receptor trafficking.
- Gene ID
- 6642
- UniProt
- Q13596
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