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SARS-CoV-2 Spike S1 antibody (RBD) Primary Antibody

Reactivity: SARS Coronavirus-2 (SARS-CoV-2) ELISA, Neut Host: Human Monoclonal unconjugated
Pubmed (5)
Catalog No. ABIN6952616
$468.00
Plus shipping costs $45.00
100 μg ABIN6952616
100 μg ABIN6952616
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  • Target
    SARS-CoV-2 Spike S1
    Antibody Type
    Recombinant Antibody
    Biological Activity
    Active
    Binding Specificity
    RBD
    • 12
    • 3
    • 3
    • 2
    • 2
    • 1
    Reactivity
    SARS Coronavirus-2 (SARS-CoV-2)
    • 39
    • 5
    Host
    Human
    • 20
    • 12
    • 3
    • 2
    • 1
    • 1
    Clonality
    Monoclonal
    • 21
    • 11
    • 7
    Conjugate
    This SARS-CoV-2 Spike S1 antibody is un-conjugated
    • 31
    • 4
    • 2
    • 1
    • 1
    Application
    ELISA, Neutralization (Neut)
    • 37
    • 10
    • 9
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Purpose
    Anti-SARS-CoV-2 neutralizing antibody (Human IgG1)
    Specificity
    The product is specific for SARS-CoV-2 Spike Protein S1 subunit and its RBD domain, and can inhibit the interaction between SARS-CoV-2 Spike Protein RBD and ACE2.
    Cross-Reactivity (Details)
    This product is a specific neutralizing antibody against SARS-CoV-2 Spike Protein RBD domain and no cross-reactivity was detected against SARS-CoV Spike protein. The cross-reactivity with other coronaviruses has not been tested yet.
    Characteristics
    Anti-SARS-CoV-2 Neutralizing Antibody, Human IgG1 recognizes the SARS-CoV-2 Spike Protein RBD domain and can inhibit the interaction between SARS-CoV-2 Spike Protein RBD and ACE2. It has not been tested with other coronovirus. It is expressed from human 293 cells (HEK293).
    Purity
    > 95 % as determined by SDS-PAGE.
    Sterility
    0.22 μm filtered
    Isotype
    IgG1
    Biological Activity Comment
    IC50 = 1.47 μg/mL using SARS-CoV-2 Inhibitor screening Kit
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4 . Normally trehalose is added as protectant before lyophilization.
    Storage
    4 °C,-20 °C,-80 °C
    Storage Comment
    For long term storage, the product should be stored at lyophilized state at -20°C or lower.
    This product is stable after storage at:
    4-8°C for 12 months in lyophilized state,
    -70°C for 3 years under sterile conditions after reconstitution.
  • Chouchane, Grivel, Farag, Pavlovski, Maacha, Sathappan, Al-Romaihi, Abuaqel, Ata, Ismail Chouchane, Remadi, Halabi, Rafii, Al-Thani, Marr, Subramanian, Shan: "Dromedary camels as a natural source of neutralizing nanobodies against SARS-CoV-2." in: JCI insight, 2021 (PubMed).

    Munitz, Edry-Botzer, Itan, Tur-Kaspa, Dicker, Marcoviciu, Goren, Mor, Lev, Gottesman, Muhsen, Cohen, Stein, Qimron, Freund, Wine, Gerlic: "Rapid seroconversion and persistent functional IgG antibodies in severe COVID-19 patients correlates with an IL-12p70 and IL-33 signature." in: Scientific reports, Vol. 11, Issue 1, pp. 3461, 2021 (PubMed).

    Apostolou, Kyritsi, Vontas, Loizou, Hadjilouka, Speletas, Mouchtouri, Hadjichristodoulou: "Development and performance characteristics evaluation of a new Bioelectric Recognition Assay (BERA) method for rapid Sars-CoV-2 detection in clinical samples." in: Journal of virological methods, Vol. 293, pp. 114166, 2021 (PubMed).

    Park, Bazzill, Son, Nam, Shin, Ochyl, Stuckey, Meagher, Chang, Song, Montefiori, LaBranche, Smith, Xu, Moon: "Lipid-based vaccine nanoparticles for induction of humoral immune responses against HIV-1 and SARS-CoV-2." in: Journal of controlled release : official journal of the Controlled Release Society, Vol. 330, pp. 529-539, 2020 (PubMed).

    Xiong, Qu, Ciazynska, Hosmillo, Carter, Ebrahimi, Ke, Scheres, Bergamaschi, Grice, Zhang, Nathan, Baker, James, Baxendale, Goodfellow, Doffinger, Briggs: "A thermostable, closed SARS-CoV-2 spike protein trimer." in: Nature structural & molecular biology, Vol. 27, Issue 10, pp. 934-941, 2020 (PubMed).

  • Target
    SARS-CoV-2 Spike S1
    Synonyms
    E2, Surface Glycoprotein, S
    Background
    Protein S (PROS1) is glycoprotein and expressed in many cell types supporting its reported involvement in multiple biological processes that include coagulation, apoptosis, cancer development and progression, and the innate immune response. Known receptors bind S1 are ACE2, DPP4, CEACAM etc.. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
    Gene ID
    43740568
    UniProt
    P0DTC2
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