PTPN12 antibody (AA 1-100) (Alexa Fluor 350)

Catalog No. ABIN6976842

Product Details anti-PTPN12 Antibody (Alexa Fluor 350)

Target: PTPN12 (Protein Tyrosine Phosphatase G1 (PTPN12))

Binding Specificity: AA 1-100

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PTPN12 antibody is conjugated to Alexa Fluor 350

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human PTPN12

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for PTPN12

Target: PTPN12 (Protein Tyrosine Phosphatase G1 (PTPN12))

Alternative Name: PTPN12 (PTPN12 Products)

Synonyms: PTP-PEST antibody, PTPG1 antibody, P19-PTP antibody, PTP-P19 antibody, Ptpg1 antibody, RKPTP antibody, protein tyrosine phosphatase, non-receptor type 12 antibody, PTPN12 antibody, Ptpn12 antibody

Background:

Synonyms: Protein tyrosine phosphatase G1, Protein tyrosine phosphatase non receptor type 12, Protein-tyrosine phosphatase G1, PTN12_HUMAN, PTP PEST, PTP-PEST, PTPG1, Ptpn12, Tyrosine protein phosphatase non receptor type 12, Tyrosine-protein phosphatase non-receptor type 12.

Background: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]

Gene ID: 5782

UniProt: Q05209