IL4 Receptor antibody (AA 171-270) (Alexa Fluor 350)

Catalog No. ABIN6977100

Product Details anti-IL4 Receptor Antibody (Alexa Fluor 350)

Target: IL4 Receptor (IL4R) (Interleukin 4 Receptor (IL4R))

Binding Specificity: AA 171-270

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL4 Receptor antibody is conjugated to Alexa Fluor 350

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Cross-Reactivity: Human

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human IL-4R

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for IL4 Receptor

Target: IL4 Receptor (IL4R) (Interleukin 4 Receptor (IL4R))

Alternative Name: IL-4R (IL4R Products)

Synonyms: IL4R antibody, il-4ra antibody, zgc:113063 antibody, CD124 antibody, IL-4RA antibody, IL4RA antibody, Il4ra antibody, IL4 antibody, Il4r antibody, interleukin 4 receptor antibody, interleukin 4 receptor, tandem duplicate 1 antibody, interleukin 4 receptor, alpha antibody, IL4R antibody, il4r.1 antibody, Il4r antibody, Il4ra antibody

Background:

Synonyms: Interleukin-4 Receptor, 582J2.1, CD124, CD-124, CD 124, IL 4R alpha, IL4RA, Interleukin 4 receptor alpha chain, MGC118473.

Background: This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Two transcript variants encoding different isoforms, a membrane-bound and a soluble form, have been found for this gene. [provided by RefSeq, Jul 2008].

Gene ID: 3566

UniProt: P24394

Pathways: JAK-STAT Signaling, Positive Regulation of Immune Effector Process