SARS-CoV-2 Spike antibody

Catalog No. ABIN6990096

Product Details anti-SARS-CoV-2 Spike Antibody

Target: SARS-CoV-2 Spike

Reactivity: SARS Coronavirus-2 (SARS-CoV-2)

Host: Human

Clonality: Monoclonal

Conjugate: This SARS-CoV-2 Spike antibody is un-conjugated

Application: ELISA

Specificity: Antibody recognizes 2019-nCoV S-RBD Protein.

Purity: 95,00%

Immunogen: Cultured in vitro under conditions free from animal derived components.

Clone: 5E8

Isotype: IgG1

Application Details

Application Notes: Immunoreactivity: 80-120 % compared to the reference sample in an ELISA test.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 5.0 mg/mL

Buffer: PBS, pH 7.4

Storage: -20 °C,4 °C

Storage Comment: 24 months from manufacturing at <-20 °C, 1 month, 2 to 8 °C under sterile conditions.

Target Details for SARS-CoV-2 Spike

Target: SARS-CoV-2 Spike

Abstract: SARS-CoV-2 Spike Products

Synonyms: E2 antibody, E2 glycoprotein precursor antibody, Surface Glycoprotein antibody, S antibody

Target Type: Viral Protein

Background: The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.

Gene ID: 43740568