BAK1 antibody (N-Term)

Catalog No. ABIN6990474

Product Details anti-BAK1 Antibody

Target: BAK1 (BCL2-Antagonist/killer 1 (BAK1))

Binding Specificity: AA 30-80, N-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BAK1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Purification: Bak Antibody is Ion exchange chromatography purified.

Immunogen: Bak antibody was raised against a peptide corresponding to 13 amino acids near the amino-terminus of human Bak. The immunogen is located within amino acids 30 - 80 of Bak.

Isotype: IgG

Application Details

Application Notes: Bak antibody can be used for detection of Bak by Western blot at 1 to 2 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 2 μ,g/mL.

Antibody validated: Western Blot in mouse samples and Immunocytochemistry in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Bak Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: Bak antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for BAK1

Target: BAK1 (BCL2-Antagonist/killer 1 (BAK1))

Alternative Name: Bak (BAK1 Products)

Synonyms: BAK antibody, BAK-LIKE antibody, BCL2L7 antibody, CDN1 antibody, Bak antibody, N-BAK1 antibody, N-Bak antibody, Bak1 antibody, bak antibody, bak1 antibody, BCL2 antagonist/killer 1 antibody, BCL2-antagonist/killer 1 antibody, BCL2 antagonist/killer 1 L homeolog antibody, BAK1 antibody, Bak1 antibody, bak1.L antibody

Background: Bak Antibody: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. The Bcl-2 family of proteins is comprised of critical regulators of apoptosis that can be divided into two classes: those that inhibit apoptosis and those that promote cell death. Bak, a pro-apoptotic Bcl-2 family member, is an oligomeric protein that localizes to the mitochondria. It is thought to share significant functional homology with Bax, another pro-apoptotic Bcl-2 family member, as disruption of bak or bax has little effect on cell death, but mice lacking both genes display multiple developmental defects and cells lacking bak and bax show decreased apoptotic capability.

Gene ID: 578

UniProt: Q16611

Pathways: Apoptosis, Steroid Hormone Mediated Signaling Pathway, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response