HVEM antibody (C-Term)

Catalog No. ABIN6990623

Product Details anti-HVEM Antibody

Target: HVEM (TNFRSF14) (Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HVEM antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Purification: TNFRSF14 Antibody is affinity chromatography purified via peptide column.

Immunogen: TNFRSF14 antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human TNFRSF14. The immunogen is located within the last 50 amino acids of TNFRSF14.

Isotype: IgG

Application Details

Application Notes: TNFRSF14 antibody can be used for the detection of TNFRSF14 by Western blot at 2 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 10 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: TNFRSF14 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: TNFRSF14 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for HVEM

Target: HVEM (TNFRSF14) (Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14))

Alternative Name: TNFRSF14 (TNFRSF14 Products)

Synonyms: ATAR antibody, CD270 antibody, HVEA antibody, HVEM antibody, LIGHTR antibody, TR2 antibody, Atar antibody, HveA antibody, Hvem antibody, Tnfrs14 antibody, TNF receptor superfamily member 14 antibody, tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) antibody, Tnfrsf14 antibody, TNFRSF14 antibody

Target Type: Viral Protein

Background: TNFRSF14 Antibody: Tumor necrosis factor receptor (TNFR) superfamily members are defined by cysteine-rich domains in their extracellular regions that bind TNF-related ligands that share a common structural homology in their extracellular domain. TNFRSF14 was initially identified as the Herpesvirus entry mediator and upon binding to the herpes simplex virus (HSV) envelope glycoprotein D or either of its natural ligands LIGHT and lymphotoxin alpha (LT), activates the transcription factors NF-κ,B and AP-1. Activation of this signal transduction pathway in T cells stimulates T cell proliferation and cytokine production, leading to inflammation and enhanced CTL-mediated tumor immunity, suggesting that these proteins may be useful as potential targets for controlling cellular immune responses.

Gene ID: 8764

UniProt: Q92956

Pathways: Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints