LGI2 antibody (N-Term)

Catalog No. ABIN6990865

Product Details anti-LGI2 Antibody

Target: LGI2 (Leucine-Rich Repeat LGI Family, Member 2 (LGI2))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LGI2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Specificity: This LGI2 antibody is predicted to be specific to LGI2 and not recognize other LGI proteins. Three isoforms of LGI2 are known to exist, this LGI2 antibody will recognize only the longest.

Purification: LGI2 Antibody is affinity chromatography purified via peptide column.

Immunogen: LGI2 antibody was raised against a 11 amino acid synthetic peptide from near the amino terminus of human LGI2. The immunogen is located within the first 50 amino acids of LGI2.

Isotype: IgG

Application Details

Application Notes: LGI2 antibody can be used for the detection of LGI2 by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: LGI2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: LGI2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for LGI2

Target: LGI2 (Leucine-Rich Repeat LGI Family, Member 2 (LGI2))

Alternative Name: LGI2 (LGI2 Products)

Synonyms: LGIL2 antibody, mKIAA1916 antibody, leucine rich repeat LGI family member 2 antibody, leucine-rich repeat LGI family, member 2 antibody, leucine-rich repeat LGI family member 2 antibody, leucine-rich repeat LGI family, member 2a antibody, LGI2 antibody, Lgi2 antibody, lgi2 antibody, lgi2a antibody

Background: LGI2 Antibody: The leucine-rich, glioma inactivated gene 2 (LGI2) is a member of the LGI family in which LGI1 is the exemplar. The LGI family consists of four of highly related proteins containing leucine-rich repeats (LRRs) which are highly similar to other transmembrane signaling molecules and receptors. LGI1 has been identified as a candidate tumor suppressor gene for glioma and plays a role in autodominant lateral temporal epilepsy (ADTLE), an epileptic syndrome characterized by focal seizures with predominant auditory symptoms. Despite its high homology with LGI1 and similar pattern of expression, mutations in LGI2 have not been found to be associated with ADTLE.

Gene ID: 246316

UniProt: Q8K4Z0, Q8N0V4