IL-34 antibody (N-Term)

Catalog No. ABIN6990969

Product Details anti-IL-34 Antibody

Target: IL-34 (IL34) (Interleukin 34 (IL34))

Binding Specificity: AA 30-80, N-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL-34 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: IL-34 Antibody is affinity chromatography purified via peptide column.

Immunogen: IL-34 antibody was raised against a 16 amino acid synthetic peptide from near the amino terminus of human IL-34. The immunogen is located within amino acids 30 - 80 of IL-34.

Isotype: IgG

Application Details

Application Notes: IL-34 antibody can be used for the detection of IL-34 by Western blot at 0.25 μ,g/mL. Despite its predicted molecular weight, IL-34 will often run at higher molecular weight in SDS-PAGE.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: IL-34 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: IL-34 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for IL-34

Target: IL-34 (IL34) (Interleukin 34 (IL34))

Alternative Name: IL-34 (IL34 Products)

Synonyms: C16orf77 antibody, IL-34 antibody, 2010004A03Rik antibody, AI593503 antibody, C18H16ORF77 antibody, interleukin 34 antibody, IL34 antibody, Il34 antibody

Background: IL-34 Antibody: Interleukin-34 (IL-34) was identified through a functional screening of a library of secreted proteins after transfection of an embryonic kidney cell line with recombinant cDNAs. Flow cytometry and monocyte viability assays demonstrated increased survival and/or proliferation of monocytes induced by IL-34 and specific binding of IL-34 to CD14+ monocytes. IL-34 is a second ligand to the colony stimulating factor (CSF)-1 receptor in addition to CSF1. Like CSF1, IL-34 stimulates phosphorylation of ERK1 and ERK2 in human monocytes and induces differentiation of bone marrow cells into macrophages.

Molecular Weight: Predicted: 26 kDa

Observed: 42-48 kDa

Gene ID: 146433

UniProt: Q6ZMJ4

Pathways: RTK Signaling