SCARB1 antibody (N-Term)

Catalog No. ABIN6991126

Product Details anti-SCARB1 Antibody

Target: SCARB1 (Scavenger Receptor Class B, Member 1 (SCARB1))

Binding Specificity: AA 70-120, N-Term

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SCARB1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: At least two isoforms of SCARB1 are known to exist, this antibody can detect both isoforms.

Purification: SCARB1 Antibody is affinity chromatography purified via peptide column.

Immunogen: SCARB1 antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human SCARB1. The immunogen is located within amino acids 70 - 120 of SCARB1.

Isotype: IgG

Application Details

Application Notes: SCARB1 antibody can be used for detection of SCARB1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: SCARB1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: SCARB1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for SCARB1

Target: SCARB1 (Scavenger Receptor Class B, Member 1 (SCARB1))

Alternative Name: SCARB1 (SCARB1 Products)

Synonyms: cb1015 antibody, SCARB1 antibody, Scarb1 antibody, CD36L1 antibody, CLA-1 antibody, CLA1 antibody, HDLQTL6 antibody, SR-BI antibody, SRB1 antibody, AI120173 antibody, CD36 antibody, Cd36l1 antibody, Cla-1 antibody, Cla1 antibody, D5Ertd460e antibody, Hdlq1 antibody, Hlb398 antibody, SR-B1 antibody, SRBI antibody, Srb1 antibody, mSR-BI antibody, scavenger receptor class B, member 1 antibody, scavenger receptor class B member 1 antibody, scarb1 antibody, SCARB1 antibody, Scarb1 antibody, CpipJ_CPIJ014332 antibody, CpipJ_CPIJ019101 antibody

Background: SCARB1 Antibody: Scavenger receptor class B member 1 (SCARB1), also known as SR-BI, is part of the scavenger receptor superfamily, which is composed of many members with diverse structures, expression patterns, and functions. SCARB1 is a multi-ligand cell-surface receptor that mediates the selective uptake of lipid from HDL cholesterol into cells and is expressed in steroidogenic tissues in adult animals. Other ligands of SCARB1 include native, acetylated, or oxidized LDL and anionic phospholipids. SCARB1-deficient mice have elevated HDL levels and increased susceptibility to atherosclerosis on fat feeding, indicating its importance in the regulation of cholesterol homeostasis. Along with CLDN1, LDL-R, and the tetraspanin superfamily member CD81, SCARB1 has been reported to be an entry factor for the Hepatitis C virus.

Molecular Weight: Predicted: 56, 60 kDa

Observed: 60 kDa

Gene ID: 949

UniProt: Q8WTV0

Pathways: Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Lipid Metabolism, SARS-CoV-2 Protein Interactome