ANAPC10 antibody (AA 60-110)
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- Target See all ANAPC10 Antibodies
- ANAPC10 (Anaphase Promoting Complex Subunit 10 (ANAPC10))
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Binding Specificity
- AA 60-110
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This ANAPC10 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)
- Purification
- APC10 Antibody is affinity chromatography purified via peptide column.
- Immunogen
- APC10 antibody was raised against a 16 amino acid synthetic peptide near the center of human APC10. The immunogen is located within amino acids 60 - 110 of APC10.
- Isotype
- IgG
- Top Product
- Discover our top product ANAPC10 Primary Antibody
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- Application Notes
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APC10 antibody can be used for detection of APC10 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.
Antibody validated: Western Blot in mouse samples, Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested. - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- APC10 Antibody is supplied in PBS containing 0.02 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,4 °C
- Storage Comment
- APC10 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- Target
- ANAPC10 (Anaphase Promoting Complex Subunit 10 (ANAPC10))
- Alternative Name
- APC10 (ANAPC10 Products)
- Synonyms
- APC10 antibody, DOC1 antibody, 1500026N15Rik antibody, A830003M23Rik antibody, CG11419 antibody, Dmel\\CG11419 antibody, ANAPC10 antibody, SPBC1E8.06 antibody, anapc10 antibody, MGC85037 antibody, DDBDRAFT_0202332 antibody, DDBDRAFT_0235160 antibody, DDB_0202332 antibody, DDB_0235160 antibody, anaphase promoting complex subunit 10 antibody, Anaphase Promoting Complex subunit 10 antibody, anaphase promoting complex subunit DOC1 antibody, anaphase-promoting complex subunit Apc10 antibody, anaphase promoting complex subunit antibody, predicted protein antibody, anaphase promoting complex subunit 10 S homeolog antibody, ANAPC10 antibody, Anapc10 antibody, APC10 antibody, DOC1 antibody, apc10 antibody, CAALFM_C107850CA antibody, anapc10 antibody, LOC692856 antibody, anapc10.S antibody, NAEGRDRAFT_66759 antibody
- Background
- APC10 Antibody: Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC10 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex. It has been suggested that APC10 plays a role to regulate the binding of specific substrates to the APC/C complex, similar to that of coactivators.
- Gene ID
- 10393
- UniProt
- Q9UM13
- Pathways
- M Phase
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