BTLA antibody (AA 170-220)

Catalog No. ABIN6991902

Product Details anti-BTLA Antibody

Target: BTLA (B and T Lymphocyte Associated (BTLA))

Binding Specificity: AA 170-220

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BTLA antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: BTLA antibody is human specific. At least two isoforms of BTLA are known to exist.

Purification: BTLA Antibody is affinity chromatography purified via peptide column.

Immunogen: BTLA antibody was raised against a 17 amino acid peptide near the center of human BTLA. The immunogen is located within amino acids 170 - 220 of BTLA .

Isotype: IgG

Application Details

Application Notes: BTLA antibody can be used for detection of BTLA by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: BTLA Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: BTLA antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for BTLA

Target: BTLA (B and T Lymphocyte Associated (BTLA))

Alternative Name: BTLA (BTLA Products)

Synonyms: BTLA antibody, BTLA1 antibody, CD272 antibody, A630002H24 antibody, B and T lymphocyte associated antibody, BTLA antibody, Btla antibody

Background: The B- and T-lymphocyte attenuator (BTLA) protein is a member of the immunoglobulin superfamily containing a single immunoglobulin (Ig) domain (1). Like other coihibitory receptors such as CTLA-4 and PD-1, BTLA functions as a receptor that relays inhibitory signals to suppress the immune response, and can inhibit LPS-induced endotoxic shock by suppressing TLR4 signaling in innate immune cells (1,2). Polymorphisms in this gene have also been associated with an increased risk of rheumatoid arthritis (3).

Molecular Weight: Predicted: 32 kDa

Observed: 40kDa

Gene ID: 151888

NCBI Accession: NP_861445

UniProt: Q7Z6A9

Pathways: Cancer Immune Checkpoints