APPBP2 antibody is human, mouse and rat reactive. At least two isoforms of APPBP2 are known to exist, this antibody will detect both isoforms.
Purification
APPBP2 antibody is affinity chromatography purified via peptide column.
Immunogen
APPBP2 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human APPBP2. The immunogen is located within the last 50 amino acids of APPBP2.
APPBP2
Reactivity: Human
WB, ELISA, IF (cc), IF (p), IHC (p), ICC, IHC (fro)
Host: Rabbit
Polyclonal
unconjugated
Application Notes
APPBP2 antibody can be used for detection of APPBP2 by Western blot at 0.5 - 1 μ,g/mL. Antibody can also be used for Immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.
Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Restrictions
For Research Use only
Format
Liquid
Concentration
1 mg/mL
Buffer
APPBP2 antibody is supplied in PBS containing 0.02 % sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C,4 °C
Storage Comment
APPBP2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Target
APPBP2
(Amyloid beta Precursor Protein (Cytoplasmic Tail) Binding Protein 2 (APPBP2))
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Background
The amyloid beta precursor protein (cytoplasmic tail) binding protein 2 (APPBP2), also known as PAT1, interacts with microtubules and is functionally associated with beta-amyloid precursor protein transport and/or processing (1). The beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease (2). APPBP2 has been found to be highly expressed in breast cancer (3).