C19ORF80 antibody (N-Term)

Catalog No. ABIN6991947

Product Details anti-C19ORF80 Antibody

Target: C19ORF80 (Chromosome 19 Open Reading Frame 80 (C19ORF80))

Binding Specificity: AA 40-90, N-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This C19ORF80 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Specificity: Betatrophin antibody is human, mouse and rat reactive. At least three isoforms of Betatrophin are known to exist, this antibody will detect the two largest isoforms.

Purification: Betatrophin antibody is affinity chromatography purified via peptide column.

Immunogen: Betatrophin antibody was raised against a 16 amino acid peptide near the amino terminus of human Betatrophin. The immunogen is located within amino acids 40 - 90 of Betatrophin.

Isotype: IgG

Application Details

Application Notes: Betatrophin antibody can be used for detection of Betatrophin by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for Immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in rat samples, Immunohistochemistry in mouse and rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Betatrophin antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: Betatrophin antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for C19ORF80

Target: C19ORF80 (Chromosome 19 Open Reading Frame 80 (C19ORF80))

Alternative Name: Betatrophin (C19ORF80 Products)

Synonyms: ANGPTL8 antibody, PRO1185 antibody, PVPA599 antibody, RIFL antibody, TD26 antibody, angiopoietin like 8 antibody, ANGPTL8 antibody

Background: The Betatrophin protein, also known as the hepatocellular carcinoma-associated protein TD26, is an adipocyte- and liver-enriched insulin targeted gene that is thought to play a role in lipid metabolism be regulating serum triglyceride levels (1,2). Betatrophin is closely related to the angiopoietin-like (ANGPTL) protein family. Betatrophin mRNA increases in the cold environment and after treatment with a high-fat diet, while its mRNA levels decrease in response to fasting, suggesting that it may play a role in mediating thermogenesis and energy homeostasis (3).

Molecular Weight: Predicted: 22 kDa

Observed: 22 kDa

Gene ID: 55908

NCBI Accession: NP_061157

UniProt: Q6UXH0