IL-11 antibody (N-Term)

Catalog No. ABIN6992179

Product Details anti-IL-11 Antibody

Target: IL-11 (IL11) (Interleukin 11 (IL11))

Binding Specificity: AA 40-90, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL-11 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Specificity: IL-11 antibody is human specific. At least two isoforms of IL-11 are known to exist, this antibody will only detect the longest isoform of IL-11.

Purification: IL-11 Antibody is affinity chromatography purified via peptide column.

Immunogen: IL-11 antibody was raised against a 16 amino acid peptide from near the amino terminus of human IL-11. The immunogen is located within amino acids 40 - 90 of IL-11.

Isotype: IgG

Application Details

Application Notes: IL-11 antibody can be used for the detection of IL-11 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunocytochemistry at 10 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: IL-11 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: IL-11 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for IL-11

Target: IL-11 (IL11) (Interleukin 11 (IL11))

Alternative Name: IL-11 (IL11 Products)

Synonyms: IL11 antibody, AGIF antibody, IL-11 antibody, Il-11 antibody, interleukin 11 antibody, IL11 antibody, Il11 antibody

Background: Interleukin 11 is a pleiotropic cytokine that has multiple effects on both hematopoietic and nonhematopoietic cells. Many of the biological effects described for IL-11 overlap those for IL-6 (1). It directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (2). IL-11 promotes the proliferation of hepatocytes in response to liver damage. IL-11 binds to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 (3). Clinically it is used to prevent severe thrombocytopenia and the reduction of the need for platelet transfusion following myelo-suppressive chemotherapy (4).

Molecular Weight: Predicted: 20 kDa

Observed: 19 kDa

Gene ID: 3589

NCBI Accession: NP_000632

UniProt: P20809

Pathways: JAK-STAT Signaling, Negative Regulation of Hormone Secretion