SLC30A8 antibody (N-Term)

Catalog No. ABIN6992184

Product Details anti-SLC30A8 Antibody

Target: SLC30A8 (Solute Carrier Family 30 (Zinc Transporter), Member 8 (SLC30A8))

Binding Specificity: N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLC30A8 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Specificity: Two isoforms of SLC30A8 are known to exist, this antibody will detect both isoforms. This SLC30A8 antibody is predicted to not cross-react with other members of the SLC30 protein family.

Purification: SLC30A8 Antibody is affinity chromatography purified via peptide column.

Immunogen: SLC30A8 antibody was raised against a peptide corresponding to 14 amino acids near the amino terminus of human SLC30A8.

Isotype: IgG

Application Details

Application Notes: SLC30A8 antibody can be used for Western blot at 1 - 2 μ,g/mL. Antibody can also be used for Immunohistochemistry starting at 10 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: SLC30A8 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: SLC30A8 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for SLC30A8

Target: SLC30A8 (Solute Carrier Family 30 (Zinc Transporter), Member 8 (SLC30A8))

Alternative Name: SLC30A8 (SLC30A8 Products)

Synonyms: C820002P14Rik antibody, ZnT-8 antibody, ZnT8 antibody, slc30a3 antibody, znt8 antibody, ZNT8 antibody, E130106K10Rik antibody, Gm212 antibody, wu:fe49g03 antibody, RGD1305098 antibody, solute carrier family 30 member 8 antibody, solute carrier family 30 (zinc transporter), member 8 antibody, solute carrier family 30 (zinc transporter), member 8 L homeolog antibody, solute carrier family 30, member 10 antibody, SLC30A8 antibody, Slc30a8 antibody, slc30a8.L antibody, slc30a8 antibody, Slc30a10 antibody

Background: SLC30A8 Antibody: SLC30A8 is a zinc efflux transporter involved in the accumulation of zinc in intracellular vesicles and is expressed at a high level in the pancreas, particularly in islets of Langerhans, and co-localizes with insulin in the secretory pathway granules of the insulin-secreting INS-1 cells (1). Allelic variants of SLC30A8 have been identified as major genetic risk factors for the development of Type 2 diabetes (2), but no genetic association has been found with Type 1 diabetes (3). SLC30A8 expression in ?-cells was found to be influenced by cytokine expression, particularly IFN-gamma and IL-1beta (4).

Molecular Weight: Predicted: 35, 41 kDa

Observed: 35, 41 kDa

Gene ID: 169026

NCBI Accession: NP_776250

UniProt: Q8IWU4

Pathways: Positive Regulation of Peptide Hormone Secretion, Hormone Transport, Carbohydrate Homeostasis, Transition Metal Ion Homeostasis