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RAG2 antibody

RAG2 Reactivity: Mouse WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7256152
  • Target See all RAG2 Antibodies
    RAG2 (Recombination Activating Gene 2 (RAG2))
    Reactivity
    • 45
    • 13
    • 12
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Mouse
    Host
    • 39
    • 6
    Rabbit
    Clonality
    • 41
    • 4
    Polyclonal
    Conjugate
    • 21
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This RAG2 antibody is un-conjugated
    Application
    • 19
    • 13
    • 13
    • 12
    • 7
    • 6
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Characteristics
    Polyclonal Antibody
    Purification
    Affinity purification
    Immunogen
    Recombinant fusion protein of human RAG2 (NP_001230715.1).
    Isotype
    IgG
    Top Product
    Discover our top product RAG2 Primary Antibody
  • Application Notes
    WB 1:500-1:2000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    RAG2 (Recombination Activating Gene 2 (RAG2))
    Alternative Name
    RAG2 (RAG2 Products)
    Synonyms
    RAG-2 antibody, Rag-2 antibody, rag-2 antibody, zgc:136743 antibody, recombination activating 2 antibody, recombination activating gene 2 antibody, recombination activating gene 2 S homeolog antibody, RAG2 antibody, Rag2 antibody, rag2 antibody, rag2.S antibody
    Background
    This gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms.
    Molecular Weight

    Observed_MW: 59 kDa

    Calculated_MW: 59 kDa

    Gene ID
    5897
    UniProt
    P55895
    Pathways
    Chromatin Binding, Production of Molecular Mediator of Immune Response
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