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Glutathione Peroxidase 2 antibody

GPX2 Reactivity: Human, Mouse, Rat IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7009224
  • Target See all Glutathione Peroxidase 2 (GPX2) Antibodies
    Glutathione Peroxidase 2 (GPX2)
    Reactivity
    • 14
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 14
    • 1
    Rabbit
    Clonality
    • 15
    Polyclonal
    Conjugate
    • 11
    • 2
    • 1
    • 1
    This Glutathione Peroxidase 2 antibody is un-conjugated
    Application
    • 9
    • 8
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC)
    Characteristics
    Polyclonal Antibody
    Purification
    Affinity purification
    Immunogen
    Recombinant fusion protein of human GPX2 (NP_002074.2).
    Isotype
    IgG
    Top Product
    Discover our top product GPX2 Primary Antibody
  • Application Notes
    IHC 1:50-1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    Glutathione Peroxidase 2 (GPX2)
    Alternative Name
    GPX2 (GPX2 Products)
    Synonyms
    ATGPX2 antibody, GLUTATHIONE PEROXIDASE antibody, T9H9.9 antibody, T9H9_9 antibody, glutathione peroxidase 2 antibody, GI-GPx antibody, GPRP antibody, GPRP-2 antibody, GPx-2 antibody, GPx-GI antibody, GSHPX-GI antibody, GSHPx-2 antibody, LOC100136264 antibody, GSHPx-GI antibody, GPX-GI antibody, glutathione peroxidase 2 antibody, glutathione peroxidase 1 antibody, GPX2 antibody, gpx1 antibody, Gpx2 antibody, LELG_01052 antibody
    Background
    The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is predominantly expressed in the gastrointestinal tract (also in liver in human), is localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. Overexpression of this gene is associated with increased differentiation and proliferation in colorectal cancer. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene.
    Gene ID
    2877
    UniProt
    P18283
    Pathways
    Thyroid Hormone Synthesis
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