LITAF antibody

Catalog No. ABIN7261431

Product Details anti-LITAF Antibody

Target: LITAF (Lipopolysaccharide-Induced Tumor Necrosis Factor-alpha Factor (LITAF))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LITAF antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Specificity: This antibody ist KO validated.

Characteristics: Polyclonal Antibody

Purification: Affinity purification

Grade: KO Validated

Immunogen: Recombinant fusion protein of human LITAF (NP_004853.2).

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000 IHC 1:50-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for LITAF

Target: LITAF (Lipopolysaccharide-Induced Tumor Necrosis Factor-alpha Factor (LITAF))

Alternative Name: LITAF (LITAF Products)

Synonyms: PIG7 antibody, SIMPLE antibody, TP53I7 antibody, EET-1 antibody, Pig7 antibody, TNF-alpha antibody, 3222402J11Rik antibody, C85531 antibody, N4WBP3 antibody, TBX1 antibody, lipopolysaccharide induced TNF factor antibody, lipopolysaccharide-induced TNF factor antibody, LPS-induced TN factor antibody, LITAF antibody, Litaf antibody

Background: Lipopolysaccharide is a potent stimulator of monocytes and macrophages, causing secretion of tumor necrosis factor-alpha (TNF-alpha) and other inflammatory mediators. This gene encodes lipopolysaccharide-induced TNF-alpha factor, which is a DNA-binding protein and can mediate the TNF-alpha expression by direct binding to the promoter region of the TNF-alpha gene. The transcription of this gene is induced by tumor suppressor p53 and has been implicated in the p53-induced apoptotic pathway. Mutations in this gene cause Charcot-Marie-Tooth disease type 1C (CMT1C) and may be involved in the carcinogenesis of extramammary Paget's disease (EMPD). Multiple alternatively spliced transcript variants have been found for this gene.

Molecular Weight:

Observed_MW: 20 kDa

Calculated_MW: 15 kDa/17 kDa/23 kDa

Gene ID: 9516

UniProt: Q99732

Pathways: Cellular Response to Molecule of Bacterial Origin