NDUFA13 antibody (AA 51-144) (HRP)

Catalog No. ABIN701329

Product Details anti-NDUFA13 Antibody (HRP)

Target: NDUFA13 (NADH Dehydrogenase (Ubiquinone) 1 alpha Subcomplex, 13 (NDUFA13))

Binding Specificity: AA 51-144

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NDUFA13 antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human GRIM19

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for NDUFA13

Target: NDUFA13 (NADH Dehydrogenase (Ubiquinone) 1 alpha Subcomplex, 13 (NDUFA13))

Alternative Name: Grim19 (NDUFA13 Products)

Synonyms: GRIM-19 antibody, Ndufa13 antibody, B16.6 antibody, CDA016 antibody, GRIM19 antibody, 2700054G14Rik antibody, AU022060 antibody, CGI-39 antibody, Grim19 antibody, RGD1565358 antibody, YJEFN3 antibody, NADH:ubiquinone oxidoreductase subunit A13 antibody, NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 antibody, cell death-regulatory protein GRIM19 antibody, GRIM-19 protein antibody, NADH:ubiquinone oxidoreductase subunit A13 L homeolog antibody, ndufa13 antibody, LOC655421 antibody, Ndufa13 antibody, CpipJ_CPIJ000908 antibody, Bm1_18845 antibody, ndufa13.L antibody, NDUFA13 antibody

Background:

Synonyms: CDA016, Cell death regulatory protein, Cell death regulatory protein GRIM-19, CGI-39, CGI39 protein, CI-B16.6, GRIM-19, GRIM 19, Complex I-B16.6, Gene associated with retinoic and N-induced mortality 19 protein, Gene associated with retinoic and interferon-induced mortality 19 protein, Gene associated with retinoic interferon induced mortality 19 protein, GRIM-19, NADH dehydrogenase ubiquinone 1 alpha subcomplex, 13, NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13, NADH ubiquinone oxidoreductase B16.6 subunit, Ndufa13.

Background: A novel gene, Genes associated with Retinoid IFN induced Mortality (GRIM) GRIM19 gene was identified. Antisense expression of GRIM19 confers a strong resistance against IFN/RA induced death by reducing the intracellular levels of GRIM19 protein. Overexpression of GRIM19 enhances cell death in response to IFN/RA. GRIM19 is primarily a nuclear protein whose expression is induced by the IFN/RA combination. These data indicate that GRIM19 is a novel cell death regulatory molecule.

Gene ID: 51079

Pathways: Protein targeting to Nucleus, Negative Regulation of intrinsic apoptotic Signaling