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CD41, CD61 antibody (PE)

Reactivity: Human FACS Host: Mouse Monoclonal PAC-1 PE
Catalog No. ABIN7013957
  • Target See all CD41, CD61 Antibodies
    CD41, CD61 (CD41,CD61)
    Reactivity
    • 12
    • 6
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 20
    Mouse
    Clonality
    • 20
    Monoclonal
    Conjugate
    • 10
    • 4
    • 3
    • 2
    • 1
    This CD41, CD61 antibody is conjugated to PE
    Application
    • 16
    • 8
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    Flow Cytometry (FACS)
    Specificity
    The mouse monoclonal antibody PAC-1 recognizes an extracellular activation-induced conformational epitope PAC-1 on CD41/CD61 complex (gpIIb/IIIa), also known as integrin alpha IIb beta 3, a receptor which mediates platelet aggregation.
    Purification
    Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
    Immunogen
    Human platelets
    Clone
    PAC-1
    Isotype
    IgM kappa
    Top Product
    Discover our top product CD41, CD61 Primary Antibody
  • Application Notes
    Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
    Restrictions
    For Research Use only
  • Buffer
    Stabilizing Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
  • Target
    CD41, CD61 (CD41,CD61)
    Alternative Name
    CD41/CD61 (CD41, CD61 Products)
    Background
    CD41 (platelet glycoprotein IIb, integrin alpha IIb) is composed of two subunits (120 kDa transmembrane alpha chain and 23 kDa extracellular beta chain) and interacts with CD61 (platelet glycoprotein IIIa, integrin beta 3) in the presence of calcium to form a functional adhesive protein receptor. CD41/CD61 complex is one of the earliest markers of the megakaryocytic lineage. Upon blood vessel damage, this receptor binds to a variety of proteins including von Willebrand factor, fibrinogen, fibronectin and vitronectin, and it is involved in platelet aggregation.,platelet GPIIb, Integrin alpha-Iib, GPalpha IIb, GPIIb, GT, GP3A, platelet GPIIIa
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