Recombinant CD59 antibody

Catalog No. ABIN7072751

The Mouse Monoclonal anti-CD59 antibody is suitable to detect CD59 in samples from Human. It has been validated for IHC, FACS and IF.

Quick Overview for Recombinant CD59 antibody (ABIN7072751)

Target: CD59

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD59 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF)

Clone: 193-27

Product Details anti-CD59 Antibody

Purpose: Anti-CD59 [193-27], Mouse IgM, kappa

Specificity: This antibody recognizes human CD59 which is a glycosyl phosphatidyl-inositol (GPI)-anchored cell surface protein. It regulates complement-mediated cell lysis, and is involved in lymphocyte signal transduction.

Characteristics:

Original Species of Ab: Mouse

Original Format of Ab: IgM

Purification: Affinity Purified using a recombinant lectin column

Immunogen: This antibody was raised by immunizng mice with stimulated human leukocytes.

Isotype: IgM kappa

Application Details

Application Notes: The antibody 193-27 is recommended for the identification and analysis of CD59 via various experimental techniques (Bellosillo et al., 2001). Genetic defects in GPI-anchor attachment, that cause a reduction or loss of CD59 and CD55 on erythrocytes produce the symptoms of the disease paroxysmal hemoglobinuria (PNH) and thus this antibody is useful for study on GPI-anchored proteins, PNH and CD59 functions.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Target Details for CD59

Target: CD59

Alternative Name: CD59

Background: 1F5, 1F5 antigen, CD59 glycoprotein, 20 kDa homologous restriction factor, HRF-20, HRF20, MAC-inhibitory protein, MAC-IP, MEM43 antigen, Membrane attack complex inhibition factor, MACIF, Membrane inhibitor of reactive lysis, MIRL, Protectin

UniProt: P13987

Pathways: Complement System