THEM4 antibody

Catalog No. ABIN7075880

Product Details anti-THEM4 Antibody

Target: THEM4 (Thioesterase Superfamily Member 4 (THEM4))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This THEM4 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Rat

Purification: Affinity purification

Immunogen: Recombinant protein corresponding to Mouse THEM4

Application Details

Application Notes: IHC/IF (M,R) 1:200-1:400/1:200-1:400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for THEM4

Target: THEM4 (Thioesterase Superfamily Member 4 (THEM4))

Alternative Name: THEM4 (THEM4 Products)

Synonyms: THEM4 antibody, CTMP antibody, 2700077M13Rik antibody, 4921507I02Rik antibody, RGD1304723 antibody, thioesterase superfamily member 4 antibody, thioesterase superfamily member 4 L homeolog antibody, THEM4 antibody, them4 antibody, Them4 antibody, them4.L antibody

Background: THEM4, also known as CTMP, binds specifically to the carboxy-terminal regulatory domain of PKB/Akt at the plasma membrane and acts as a negative regulator, reversing the phenotype of v-Akt-transformed cells. Hypermethylation of the THEM4 promoter and transcriptional downregulation of the gene has been reported in multiple glioblastomas, suggesting that epigenetic regulation of THEM4 may play a role in the progression of this cancer.

Gene ID: 75778

NCBI Accession: NP_083707

UniProt: Q3UUI3

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway