TFG antibody

Catalog No. ABIN7076022

Product Details anti-TFG Antibody

Target: TFG (Trk-Fused Gene (TFG))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TFG antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Affinity purification

Immunogen: Recombinant protein corresponding to Human TRK fused gene

Application Details

Application Notes: WB (H) 1:500- 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for TFG

Target: TFG (Trk-Fused Gene (TFG))

Alternative Name: TRK fused gene (TFG Products)

Synonyms: wu:fb11c10 antibody, zgc:55342 antibody, zgc:77230 antibody, HMSNP antibody, SPG57 antibody, TF6 antibody, TRKT3 antibody, AI173908 antibody, trk-fused gene antibody, TRK-fused gene antibody, Trk-fused gene antibody, tfg antibody, TFG antibody, Tfg antibody

Background: Protein TFG (TRK-fused gene protein) plays a role in regulating phosphotyrosine-specific phosphatase-1 activity. Mutations in TFG may have important clinical relevance for current therapeutic strategies to treat metastatic melanoma. Defects in TFG are a cause of thyroid papillary carcinoma (TPC), a common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Recent genetic investigation indicates that formation of TFG-containing cytoplasmic inclusions and concomitant mislocalization of TAR DNA-binding protein 43 kDa (TDP-43) underlie motor neuron degeneration in HMSN-P. Pathological overlap of proteinopathies involving TFG and TDP-43 highlights a new pathway leading to motor neuron degeneration.

Molecular Weight: 55 kDa

Gene ID: 10342

UniProt: Q92734