F2RL3 antibody (AA 101-200)
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- Target See all F2RL3 Antibodies
- F2RL3 (Coagulation Factor II (Thrombin) Receptor-Like 3 (F2RL3))
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Binding Specificity
- AA 101-200
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This F2RL3 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA
- Cross-Reactivity
- Human, Mouse, Rat
- Predicted Reactivity
- Cow,Rabbit
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human PAWR
- Isotype
- IgG
- Top Product
- Discover our top product F2RL3 Primary Antibody
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- Application Notes
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WB 1:300-5000
ELISA 1:500-1000 - Restrictions
- For Research Use only
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- Concentration
- 1 μg/μL
- Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Expiry Date
- 12 months
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- Target
- F2RL3 (Coagulation Factor II (Thrombin) Receptor-Like 3 (F2RL3))
- Alternative Name
- Par-4 (F2RL3 Products)
- Synonyms
- F2RL3 antibody, PAR4 antibody, F2R like thrombin or trypsin receptor 3 antibody, F2R like thrombin/trypsin receptor 3 antibody, coagulation factor II (thrombin) receptor-like 3 antibody, F2RL3 antibody, F2rl3 antibody
- Background
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Synonyms: 2310001G03Rik , PAR 4 , PAR-4 , Pawr , PAWR_HUMAN , PRKC Apoptosis WT1 Regulator , PRKC apoptosis WT1 regulator protein , Prostate apoptosis response 4 protein , Prostate apoptosis response protein 4 , prostate apoptosis response protein PAR-4 , Transcriptional repressor Par-4-like protein PAWR , Transcriptional repressor PAR4 , WT1 Interacting Protein
Background: Pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1.
- Gene ID
- 5074
- UniProt
- Q96IZ0
- Pathways
- Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process
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