APOB antibody (AA 592-689)
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- Target See all APOB Antibodies
- APOB (Apolipoprotein B (APOB))
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Binding Specificity
- AA 592-689
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This APOB antibody is un-conjugated
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Application
- Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
- Specificity
- Post-transcriptional editing of apolipoprotein B (apoB) mRNA is regulated byAPOBEC1 (also designated human (or rat) small intestinal apolipoprotein BmRNA editing protein, HEPR or REPR) in hepatic cells to achieve a steadystate proportion of edited and unedited RNA molecules. Two forms of apoBare known to circulate in the plasma of mammals. ApoB-100 is a proteinprimarily synthesized in the liver as a structural component of very low densitylipoprotein particles. A truncated form of apoB-100, apoB-48, is synthesizedin the small intestine and contains the amino-terminal 2,152 amino acids ofthe larger protein. This organ-specific partitioning of apoB production is theresultof RNA editing of a common apoB gene.
- Cross-Reactivity (Details)
- Human.
- Purification
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- Immunogen
- Human recombinant APOB protein fragment (around aa592-689) (exact sequence is proprietary)
- Isotype
- IgG2b
- Top Product
- Discover our top product APOB Primary Antibody
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- Application Notes
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Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.
Positive_Control: Human liver or kidney tissue.
- Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- Preservative
- Azide free
- Storage
- -20 °C,-80 °C
- Storage Comment
- Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- Expiry Date
- 24 months
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- Target
- APOB (Apolipoprotein B (APOB))
- Alternative Name
- APOB (APOB Products)
- Synonyms
- FLDB antibody, LDLCQ4 antibody, Ac1-060 antibody, Apo B-100 antibody, ApoB-100 antibody, ApoB-48 antibody, AI315052 antibody, apob-100 antibody, apob-48 antibody, APOB-100 antibody, ApoB(100) antibody, APOB antibody, apolipoprotein B antibody, APOB antibody, Apob antibody
- Background
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ApoB 100, ApoB 48, Apolipoprotein B (including Ag(x) antigen), Apolipoprotein B 100, Apolipoprotein B 48, Apolipoprotein B, FLDB, LDLCQ4,Apolipoprotein B /APOB
Cellular localisation: Cytoplasm. Secreted. - Molecular Weight
- 512kDa
- Gene ID
- 338, 120759
- UniProt
- P04114
- Pathways
- Lipid Metabolism
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