Aquaporin 4 antibody (AA 254-323)
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- Target See all Aquaporin 4 (AQP4) Antibodies
- Aquaporin 4 (AQP4)
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Binding Specificity
- AA 254-323
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This Aquaporin 4 antibody is un-conjugated
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Application
- Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
- Specificity
- In skeletal muscle, AQP4 (aquaporin 4 also known as mercurial insensitive water channel), localizes to the sarcolemma of fast-twitch muscle fibers. Aquaporins (AQPs) are a large family of integral membrane water transport channel proteins that facilitate the transport of water through the cell membrane. This function is conserved in animals, plants and bacteria. Many isoforms of aquaporin have been identified in mammals, designated AQP0through AQP10. Aquaporins are widely distributed and it is not uncommon for more than one type of AQP to be present in the same cell. Although most aquaporins are only permeable to water, AQP3, AQP7, AQP9 and one of the two AQP10 transcripts are also permeable to urea and glycerol. AQP2 is the only water channel that is activated by vasopressin to enhance water reabsorption in the kidney collecting duct. Aquaporins are involved in renal water absorption, generation of pulmonary secretions, lacrimation and the secretion and reabsorption of cerebrospinal fluid and aqueous humor.
- Cross-Reactivity (Details)
- Human.
- Purification
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- Immunogen
- Human recombinant AQP4 protein fragment (around aa254-323) (exact sequence is proprietary)
- Isotype
- IgG1
- Top Product
- Discover our top product AQP4 Primary Antibody
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- Application Notes
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Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.
Positive_Control: Human skeletal muscle, small intestine or brain tissue.
- Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- Preservative
- Azide free
- Storage
- -20 °C,-80 °C
- Storage Comment
- Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- Expiry Date
- 24 months
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- Target
- Aquaporin 4 (AQP4)
- Alternative Name
- AQP4 (AQP4 Products)
- Synonyms
- zgc:100922 antibody, si:ch211-192k9.1 antibody, AQP4 antibody, LOC100232616 antibody, HMIWC2 antibody, MIWC antibody, WCH4 antibody, AQP-4 antibody, AQP4.M23 antibody, MIWC2 antibody, Miwc antibody, aquaporin-4 antibody, aquaporin 4 antibody, aquaporin 4 L homeolog antibody, aqp4 antibody, AQP4 antibody, aqp4.L antibody, Aqp4 antibody
- Background
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WCH4, Mercurial-insensitive water channel (MIWC), HMIWC2,Aquaporin 4 (AQP4)
Cellular localisation: Membrane. - Molecular Weight
- 34kDa
- Gene ID
- 361, 315369
- UniProt
- P55087
- Pathways
- Sensory Perception of Sound
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