NR1H2 antibody
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- Target See all NR1H2 Antibodies
- NR1H2 (Nuclear Receptor Subfamily 1, Group H, Member 2 (NR1H2))
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This NR1H2 antibody is un-conjugated
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Application
- ELISA, Coating (Coat)
- Specificity
- The liver X receptors, LXRA (NR1H3) and LXRB (NR1H2) form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors and regulate expression of target genes containing LXR response elements. LXRB can inhibit proliferation and induce apoptosis of cancer cells.
- Cross-Reactivity (Details)
- Human.
- Purification
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- Immunogen
- Recombinant full-length human NR1H2 (LXRB) protein
- Isotype
- IgG2
- Top Product
- Discover our top product NR1H2 Primary Antibody
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- Application Notes
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Known_Application: ELISA (For coating, order Ab without BSA), Optimal dilution for a specific application should be determined.
Positive_Control: HeLa, SW480 or A549 cells. Liver.
- Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- Preservative
- Azide free
- Storage
- -20 °C,-80 °C
- Storage Comment
- Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- Expiry Date
- 24 months
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- Target
- NR1H2 (Nuclear Receptor Subfamily 1, Group H, Member 2 (NR1H2))
- Alternative Name
- NR1H2 (NR1H2 Products)
- Synonyms
- NR1H2 antibody, lxr-b antibody, lxrb antibody, ner antibody, ner-i antibody, rip15 antibody, unr antibody, DKFZp468A0622 antibody, AI194859 antibody, LXR antibody, LXRB antibody, LXRbeta antibody, NER1 antibody, OR-1 antibody, RIP15 antibody, UR antibody, Unr antibody, Unr2 antibody, LXR-b antibody, NER antibody, NER-I antibody, UNR antibody, nuclear receptor subfamily 1 group H member 2 antibody, nuclear receptor subfamily 1, group H, member 2 antibody, nuclear receptor subfamily 1 group H member 2 L homeolog antibody, NR1H2 antibody, nr1h2 antibody, Nr1h2 antibody, nr1h2.L antibody
- Background
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Liver X nuclear receptor beta, Liver X receptor beta, LX receptor beta, LXR beta, LXRB, NER1, Nuclear orphan receptor LXR beta, Nuclear receptor NER, Nuclear receptor subfamily 1 group H member 2 (NR1H2), OR-1, Oxysterols receptor LXR-beta, RIP15, Steroid hormone nuclear receptor NER, Ubiquitously-expressed nuclear receptor (UNR),Liver X Receptor beta (LXRB) (Orphan Receptor)
Cellular localisation: Nuclear - Molecular Weight
- 56kDa
- Gene ID
- 7376, 432976
- UniProt
- P55055
- Pathways
- Nuclear Receptor Transcription Pathway, Retinoic Acid Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Nuclear Hormone Receptor Binding
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