beta 2 Adrenergic Receptor antibody (pSer346)

Catalog No. ABIN7138567

Product Details anti-beta 2 Adrenergic Receptor Antibody

Target: beta 2 Adrenergic Receptor (ADRB2) (Adrenergic, beta-2-, Receptor, Surface (ADRB2))

Binding Specificity: pSer346

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This beta 2 Adrenergic Receptor antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Cross-Reactivity: Human

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogen: Peptide sequence around phosphorylation site of serine 346 (R-S-S(p)-L-K) derived from Human Adrenergic Receptor beta2.

Isotype: IgG

Application Details

Application Notes: WB:1:500-1:1000,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for beta 2 Adrenergic Receptor

Target: beta 2 Adrenergic Receptor (ADRB2) (Adrenergic, beta-2-, Receptor, Surface (ADRB2))

Alternative Name: ADRB2 (ADRB2 Products)

Synonyms: zgc:162188 antibody, adrb2 antibody, Adrb-2 antibody, Badm antibody, Gpcr7 antibody, ADRB2R antibody, ADRBR antibody, B2AR antibody, BAR antibody, BETA2AR antibody, adrenoceptor beta 2 antibody, adrenoceptor beta 2, surface b antibody, beta2-adrenergic receptor antibody, adrenergic receptor, beta 2 antibody, ADRB2 antibody, adrb2b antibody, LOC100136153 antibody, Adrb2 antibody

Background:

Background:

Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.

Gao S, Malbon C, Wang HY (2014) J Mol Signal 9, 3
24690384 Curated Info
Vistein R, Puthenveedu MA (2013) Proc Natl Acad Sci U S A 110, 15289-94
Gimenez LE, et al. (2012) J Biol Chem 287, 9028-40

Aliases: ADRB2 antibody, ADRB2_HUMAN antibody, ADRB2R antibody, ADRBR antibody, Adrenergic beta 2 receptor surface antibody, Adrenoceptor beta 2 surface antibody, B2AR antibody, BAR antibody, beta 2 adrenoceptor antibody, Beta 2 adrenoreceptor antibody, Beta-2 adrenergic receptor antibody, Beta-2 adrenoceptor antibody, Beta-2 adrenoreceptor antibody, BETA2AR antibody, Catecholamine receptor antibody, OTTHUMP00000160386 antibody

UniProt: P07550

Pathways: cAMP Metabolic Process, Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Brown Fat Cell Differentiation