CD44 antibody (pSer706)

Catalog No. ABIN7138684

Product Details anti-CD44 Antibody

Target: CD44

Binding Specificity: pSer706

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CD44 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Cross-Reactivity: Human, Mouse, Rat

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogen: Peptide sequence around phosphorylation site of serine 706 (S-K-S(p)-Q-E) derived from Human CD44.

Isotype: IgG

Application Details

Application Notes: WB:1:500-1:1000,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for CD44

Target: CD44

Alternative Name: CD44 (CD44 Products)

Synonyms: CDW44 antibody, CSPG8 antibody, ECMR-III antibody, HCELL antibody, HUTCH-I antibody, IN antibody, LHR antibody, MC56 antibody, MDU2 antibody, MDU3 antibody, MIC4 antibody, Pgp1 antibody, AU023126 antibody, AW121933 antibody, AW146109 antibody, HERMES antibody, Ly-24 antibody, Pgp-1 antibody, CD44A antibody, METAA antibody, RHAMM antibody, XCD44 antibody, cd44 antibody, cdw44 antibody, cspg8 antibody, ecmr-iii antibody, hcell antibody, lhr antibody, mc56 antibody, mdu2 antibody, mdu3 antibody, mic4 antibody, mutch-i antibody, pgp1 antibody, CD44 molecule (Indian blood group) antibody, syndecan 4 antibody, CD44 antigen antibody, CD44 molecule (Indian blood group) S homeolog antibody, CD44 antibody, SDC4 antibody, Cd44 antibody, cd44.S antibody

Background:

Background:

Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events.

Ildefonso CJ, et al. (2012)J Biol Chem 287, 32697-707. Pivetta E, et al. (2011)J Cell Physiol 226, 769-79. Wang YT, et al. (2010)J Proteome Res 9, 5582-97.

Aliases: LHR antibody, BA-1 antibody, CD 44 antibody, CD44 antibody, CD44 antigen antibody, CD44 Molecule (Indian blood group) antibody, CD44 Molecule antibody, CD44_HUMAN antibody, CDw44 antibody, CDW44 antigen antibody, Cell surface glycoprotein CD44 antibody, chondroitin sulfate proteoglycan 8 antibody, CSPG8 antibody, ECMR-III antibody, Epican antibody, Extracellular matrix receptor III antibody, GP90 lymphocyte homing/adhesion receptor antibody, HCELL antibody, hematopoietic cell E- and L-selectin ligand antibody, Heparan sulfate proteoglycan antibody, Hermes antigen antibody, homing function and Indian blood group system antibody, HSA antibody, HUTCH-I antibody, HUTCH1 antibody, HUTCHI antibody, Hyaluronate receptor antibody, IN antibody, INLU-related p80 Glycoprotein antibody, MC56 antibody, MDU2 antibody, MDU3 antibody, MGC10468 antibody, MIC4 antibody, MUTCH I antibody, MUTCH1 antibody, PGP-1 antibody, PGP-I antibody, PGP1 antibody, Phagocytic glycoprotein 1 antibody, Phagocytic glycoprotein I antibody, Soluble CD44 antibody

UniProt: P16070

Pathways: Glycosaminoglycan Metabolic Process, Autophagy, Negative Regulation of intrinsic apoptotic Signaling