NFKB2 antibody (pSer872)

Catalog No. ABIN7138764

Product Details anti-NFKB2 Antibody

Target: NFKB2 (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 2 (NFKB2))

Binding Specificity: pSer872

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NFKB2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Cross-Reactivity: Human, Mouse

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogen: Peptide sequence around phosphorylation site of serine872(S-Q-S(p)-V-E) derived from Human NF-κ,B p100 .

Isotype: IgG

Application Details

Application Notes: WB:1:500-1:1000,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for NFKB2

Target: NFKB2 (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 2 (NFKB2))

Alternative Name: NFKB2 (NFKB2 Products)

Synonyms: NF-kappaB2 antibody, lyt antibody, p49 antibody, p49/p100 antibody, p50B antibody, p52 antibody, nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100 antibody, Nfkb2 antibody

Background:

Background: NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Qu Z, Qing G, Rabson A, Xiao G (2004) J Biol Chem 279, 44563-72 . Xiao G, Fong A, Sun SC (2004) J Biol Chem 279, 30099-105 .

Aliases: CVID10 antibody, DNA binding factor KBF2 antibody, DNA-binding factor KBF2 antibody, H2TF1 antibody, Lymphocyte translocation chromosome 10 antibody, Lymphocyte translocation chromosome 10 protein antibody, Lyt 10 antibody, Lyt10 antibody, NF kB2 antibody, NFKB2 antibody, NFKB2_HUMAN antibody, Nuclear factor NF kappa B p100 subunit antibody, Nuclear factor NF kappa B p52 subunit antibody, Nuclear factor NF-kappa-B p52 subunit antibody, Nuclear factor of kappa light chain gene enhancer in B cells 2 antibody, Nuclear factor of kappa light polypeptide gene enhancer in B cells 2 antibody, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 antibody, Oncogene Lyt 10 antibody, Oncogene Lyt-10 antibody, p105 antibody, p49/p100 antibody

UniProt: Q00653

Pathways: Toll-Like Receptors Cascades