KRT17 antibody (AA 1-441) (Biotin)

Catalog No. ABIN7140839

Product Details anti-KRT17 Antibody (Biotin)

Target: KRT17 (Keratin 17 (KRT17))

Binding Specificity: AA 1-441

Reactivity: Cow

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KRT17 antibody is conjugated to Biotin

Application: ELISA

Cross-Reactivity: Cow

Purification: >95%, Protein G purified

Immunogen: Recombinant Bovine Keratin, type I cytoskeletal 17 protein (1-441AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for KRT17

Target: KRT17 (Keratin 17 (KRT17))

Alternative Name: KRT17 (KRT17 Products)

Synonyms: K17 antibody, Krt1-17 antibody, PC antibody, PC2 antibody, PCHC1 antibody, Ka17 antibody, KRT17 antibody, krt16 antibody, si:dkeyp-113d7.7 antibody, KRT14 antibody, keratin 17 antibody, keratin 17 L homeolog antibody, keratin 17, type I antibody, keratin, type I cytoskeletal 17 antibody, Krt17 antibody, KRT17 antibody, krt17 antibody, krt17.L antibody, LOC100737113 antibody, LOC102177275 antibody

Background:

Background: Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial \"stem cells\". Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors. May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation.

Aliases: KRT17 antibody, Keratin antibody, type I cytoskeletal 17 antibody, Cytokeratin-17 antibody, CK-17 antibody, Keratin-17 antibody, K17 antibody

UniProt: A1L595