PDK4 antibody (AA 143-333) (HRP)

Catalog No. ABIN7142011

This anti-PDK4 antibody is a Rabbit Polyclonal antibody detecting PDK4 in ELISA. Suitable for Human.

Quick Overview for PDK4 antibody (AA 143-333) (HRP) (ABIN7142011)

Target: PDK4 (Pyruvate Dehydrogenase Kinase, Isozyme 4 (PDK4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDK4 antibody is conjugated to HRP

Application: ELISA

Product Details anti-PDK4 Antibody (HRP)

Binding Specificity: AA 143-333

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial protein (143-333AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for PDK4

Target: PDK4 (Pyruvate Dehydrogenase Kinase, Isozyme 4 (PDK4))

Alternative Name: PDK4

Background:

Background: Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism in response to prolonged fasting and starvation. Plays an important role in maintaining normal blood glucose levels under starvation, and is involved in the insulin signaling cascade. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. In the fed state, mediates cellular responses to glucose levels and to a high-fat diet. Regulates both fatty acid oxidation and de novo fatty acid biosynthesis. Plays a role in the generation of reactive oxygen species. Protects detached epithelial cells against anoikis. Plays a role in cell proliferation via its role in regulating carbohydrate and fatty acid metabolism.

Aliases: [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4 antibody, FLJ40832 antibody, mitochondrial antibody, Pdk4 antibody, PDK4_HUMAN antibody, Pyruvate dehydrogenase [lipoamide] kinase isozyme 4 mitochondrial antibody, Pyruvate dehydrogenase kinase 4 antibody, Pyruvate dehydrogenase kinase isoenzyme 4 antibody, Pyruvate dehydrogenase kinase isoform 4 antibody, Pyruvate dehydrogenase kinase isozyme 4 antibody, Pyruvate dehydrogenase kinase isozyme 4 mitochondrial antibody

UniProt: Q16654

Pathways: PI3K-Akt Signaling, Hedgehog Signaling, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process, Warburg Effect