N-Cadherin antibody (AA 746-906) (Biotin)

Catalog No. ABIN7146225

Product Details anti-N-Cadherin Antibody (Biotin)

Target: N-Cadherin (CDH2) (Cadherin 2 (CDH2))

Binding Specificity: AA 746-906

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This N-Cadherin antibody is conjugated to Biotin

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Cadherin-2 protein (746-906AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for N-Cadherin

Target: N-Cadherin (CDH2) (Cadherin 2 (CDH2))

Alternative Name: CDH2 (CDH2 Products)

Synonyms: CD325 antibody, CDHN antibody, CDw325 antibody, NCAD antibody, N-cadherin antibody, cadherin-2 antibody, cdhn antibody, ncad antibody, cdw325 antibody, CDH2 antibody, Cadherin-2 antibody, Ncad antibody, glo antibody, lyr antibody, pac antibody, wu:fb47h04 antibody, cadherin 2 antibody, cadherin 2 S homeolog antibody, cadherin 2, type 1, N-cadherin (neuronal) antibody, CDH2 antibody, cdh2.S antibody, cdh2 antibody, Cdh2 antibody

Background:

Background: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells, cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density (By similarity).

Aliases: CADH2_HUMAN antibody, Cadherin 2 antibody, Cadherin 2 N cadherin neuronal antibody, Cadherin 2 type 1 antibody, Cadherin 2 type 1 N cadherin neuronal antibody, Cadherin 2, type 1, N-cadherin (neuronal) antibody, Cadherin-2 antibody, Cadherin2 antibody, Calcium dependent adhesion protein neuronal antibody, CD325 antibody, CD325 antigen antibody, CDH2 antibody, CDHN antibody, CDw325 antibody, CDw325 antigen antibody, N cadherin 1 antibody, N-cadherin antibody, NCAD antibody, Neural cadherin antibody, OTTHUMP00000066304 antibody, OTTHUMP00000067378 antibody

UniProt: P19022

Pathways: Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Synaptic Membrane