CH25H antibody (AA 142-272) (FITC)
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- Target See all CH25H Antibodies
- CH25H (Cholesterol 25-Hydroxylase (CH25H))
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Binding Specificity
- AA 142-272
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This CH25H antibody is conjugated to FITC
- Application
- Please inquire
- Cross-Reactivity
- Human
- Purification
- >95%, Protein G purified
- Immunogen
- Recombinant Human Cholesterol 25-hydroxylase protein (142-272AA)
- Isotype
- IgG
- Top Product
- Discover our top product CH25H Primary Antibody
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- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- CH25H (Cholesterol 25-Hydroxylase (CH25H))
- Alternative Name
- CH25H (CH25H Products)
- Synonyms
- CH25H antibody, zgc:101688 antibody, MGC143045 antibody, C25H antibody, AI462618 antibody, m25OH antibody, cholesterol 25-hydroxylase antibody, cholesterol 25-hydroxylase L homeolog antibody, CH25H antibody, ch25h antibody, Ch25h antibody, ch25h.L antibody
- Background
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Background: Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes (PubMed:9852097). Plays a key role in cell positioning and movement in lymphoid tissues: 25-hydroxycholesterol is an intermediate in biosynthesis of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC), an oxysterol that acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells. May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing. In testis, production of 25-hydroxycholesterol by macrophages may play a role in Leydig cell differentiation.
Aliases: CH25H antibody, Cholesterol 25-hydroxylase antibody, EC 1.14.99.38 antibody, Cholesterol 25-monooxygenase antibody, h25OH antibody
- UniProt
- O95992
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