AFT7 antibody (AA 1-117)

Catalog No. ABIN7148809

Product Details anti-AFT7 Antibody

Target: AFT7 (Activating Transcription Factor 7 (AFT7))

Binding Specificity: AA 1-117

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AFT7 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Cyclic AMP-dependent transcription factor ATF-7 protein (1-117AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for AFT7

Target: AFT7 (Activating Transcription Factor 7 (AFT7))

Alternative Name: ATF7 (AFT7 Products)

Synonyms: ATFA antibody, 1110012F10Rik antibody, 9430065F09Rik antibody, AI549878 antibody, C130020M04Rik antibody, ATF7 antibody, fa97a09 antibody, fc25b12 antibody, wu:fa97a09 antibody, wu:fc25b12 antibody, atfa antibody, activating transcription factor 7 antibody, activating transcription factor 7b antibody, ATF7 antibody, Atf7 antibody, atf7b antibody, atf7 antibody

Background:

Background: Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5\\\'-GTGACGT[AG][AG]-3\\\'), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family. Isoform 4/ATF-A0 acts as a dominant repressor of the E-selectin/NF-ELAM1/delta-A promoter. Isoform 5/ATF-4 acts as a negative regulator, inhibiting both ATF2 and ATF7 transcriptional activities. It may exert these effects by sequestrating in the cytoplasm the Thr-53 phosphorylating kinase, preventing activation.

Aliases: 1110012F10Rik antibody, 9430065F09Rik antibody, Activating transcription factor 7 antibody, AI549878 antibody, ATF7 antibody, Atf7 protein antibody, ATF7_HUMAN antibody, ATFA antibody, C130020M04Rik antibody, cAMP-dependent transcription factor ATF-7 antibody, Cyclic AMP-dependent transcription factor ATF 7 antibody, Cyclic AMP-dependent transcription factor ATF-7 antibody, MGC31554 antibody, MGC57182 antibody, Transcription factor ATF A antibody, Transcription factor ATF-A antibody

UniProt: P17544