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GRP78 antibody (AA 25-293) (HRP)

HSPA5 Reactivity: Human ELISA Host: Rabbit Polyclonal HRP
Catalog No. ABIN7151666
  • Target See all GRP78 (HSPA5) Antibodies
    GRP78 (HSPA5) (Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) (HSPA5))
    Binding Specificity
    • 27
    • 16
    • 13
    • 8
    • 7
    • 6
    • 6
    • 6
    • 5
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 25-293
    Reactivity
    • 201
    • 126
    • 108
    • 38
    • 38
    • 36
    • 34
    • 32
    • 31
    • 20
    • 15
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 139
    • 97
    • 8
    • 3
    • 1
    • 1
    Rabbit
    Clonality
    • 144
    • 106
    Polyclonal
    Conjugate
    • 97
    • 21
    • 18
    • 13
    • 13
    • 12
    • 9
    • 8
    • 8
    • 8
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This GRP78 antibody is conjugated to HRP
    Application
    • 218
    • 103
    • 87
    • 86
    • 77
    • 34
    • 31
    • 29
    • 26
    • 19
    • 13
    • 7
    • 6
    • 3
    • 3
    • 2
    • 1
    ELISA
    Cross-Reactivity
    Human
    Purification
    >95%, Protein G purified
    Immunogen
    Recombinant Human Endoplasmic reticulum chaperone BiP protein (25-293AA)
    Isotype
    IgG
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    Discover our top product HSPA5 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    GRP78 (HSPA5) (Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) (HSPA5))
    Alternative Name
    HSPA5 (HSPA5 Products)
    Synonyms
    GRP78 antibody, BiP antibody, GRP-78 antibody, grp78 antibody, hspa5a antibody, BIP antibody, MIF2 antibody, AL022860 antibody, AU019543 antibody, Bip antibody, D2Wsu141e antibody, D2Wsu17e antibody, Grp78 antibody, Hsce70 antibody, SEZ-7 antibody, Sez7 antibody, baffled antibody, mBiP antibody, cb865 antibody, fb60h09 antibody, fi36d04 antibody, wu:fb60h09 antibody, wu:fi36d04 antibody, zgc:55994 antibody, zgc:77606 antibody, 78 kDa glucose-regulated protein antibody, heat shock protein family A (Hsp70) member 5 antibody, BiP/GRP78 antibody, glucose-regulated protein 78 antibody, putative glucose-regulated protein 78 antibody, Hsp70 family ATPase KAR2 antibody, heat shock protein family A (Hsp70) member 5 S homeolog antibody, heat shock 70 kDa protein 5a antibody, heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) antibody, heat shock protein 5 antibody, heat shock protein family A member 5 antibody, CpipJ_CPIJ003550 antibody, HSPA5 antibody, grp78 antibody, LOC100533358 antibody, BiP/grp78 antibody, Tc00.1047053506585.40 antibody, Tb11.02.5450 antibody, Tb11.02.5500 antibody, LMJF_28_1200 antibody, KAR2 antibody, LOC100135840 antibody, hspa5.S antibody, hspa5 antibody, Hspa5 antibody
    Background

    Background: Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (PubMed:2294010, PubMed:23769672, PubMed:23990668, PubMed:28332555). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) (PubMed:1550958, PubMed:19538957). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to disrupt the dimerization of ERN1/IRE1, thereby inactivating ERN1/IRE1 (By similarity). Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP from ERN1/IRE1, allowing homodimerization and subsequent activation of ERN1/IRE1 (By similarity). Plays an auxiliary role in post-translational transport of small presecretory proteins across endoplasmic reticulum (ER). May function as an allosteric modulator for SEC61 channel-forming translocon complex, likely cooperating with SEC62 to enable the productive insertion of these precursors into SEC61 channel. Appears to specifically regulate translocation of precursors having inhibitory residues in their mature region that weaken channel gating.

    Aliases: 78 kDa glucose regulated protein antibody, 78 kDa glucose-regulated protein antibody, AL022860 antibody, AU019543 antibody, BIP antibody, D2Wsu141e antibody, D2Wsu17e antibody, Endoplasmic reticulum lumenal Ca(2+)-binding protein grp78 antibody, Endoplasmic reticulum lumenal Ca2+ binding protein grp78 antibody, Epididymis secretory sperm binding protein Li 89n antibody, FLJ26106 antibody, Glucose Regulated Protein 78 antibody, Glucose Regulated Protein 78 kDa antibody, GRP 78 antibody, GRP-78 antibody, GRP78 antibody, GRP78_HUMAN antibody, Heat shock 70 kDa protein 5 antibody, Heat Shock 70 kDa Protein 5 antibody, Heat shock protein family A (Hsp70) member 5 antibody, HEL S 89n antibody, Hsce70 antibody, HSPA 5 antibody, HSPA5 antibody, Immunoglobulin Heavy Chain Binding Protein antibody, Immunoglobulin heavy chain-binding protein antibody, mBiP antibody, MIF2 antibody, Sez7 antibody

    UniProt
    P11021
    Pathways
    Thyroid Hormone Synthesis, ER-Nucleus Signaling
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