PPP1CC antibody (Catalytic Subunit) (HRP)

Catalog No. ABIN7169315

Product Details anti-PPP1CC Antibody (HRP)

Target: PPP1CC (Protein Phosphatase 1, Catalytic Subunit, gamma Isoform (PPP1CC))

Binding Specificity: AA 151-323, Catalytic Subunit

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PPP1CC antibody is conjugated to HRP

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Serine/threonine-protein phosphatase PP1-gamma catalytic subunit protein (151-323AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for PPP1CC

Target: PPP1CC (Protein Phosphatase 1, Catalytic Subunit, gamma Isoform (PPP1CC))

Alternative Name: PPP1CC (PPP1CC Products)

Synonyms: PP-1G antibody, ppp1g antibody, PP1 antibody, dis2m1 antibody, fe06g11 antibody, fi22e08 antibody, wu:fe06g11 antibody, wu:fi22e08 antibody, PP1C antibody, PPP1G antibody, Ppp1cc1 antibody, ppp1cc-a antibody, protein phosphatase 1, catalytic subunit, gamma isozyme antibody, protein phosphatase 1, catalytic subunit, gamma isoform antibody, protein phosphatase 1 catalytic subunit gamma antibody, protein phosphatase 1, catalytic subunit, gamma isozyme L homeolog antibody, ppp1cc antibody, Ppp1cc antibody, PPP1CC antibody, ppp1cc.L antibody

Background:

Background: Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the \'Ser-418\' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208).

Aliases: PP 1G antibody, PP-1G antibody, PP1C antibody, PP1G antibody, PP1G_HUMAN antibody, PP1gamma antibody, PPP 1G antibody, PPP1CC antibody, PPP1G antibody, Protein phosphatase 1, catalytic subunit, gamma isozyme antibody, Protein phosphatase 1C catalytic subunit antibody, Serine/threonine phosphatase 1 gamma antibody, Serine/threonine protein phosphatase PP1 gamma catalytic subunit antibody, Serine/threonine-protein phosphatase PP1-gamma catalytic subunit antibody

UniProt: P36873

Pathways: Cellular Glucan Metabolic Process, Lipid Metabolism