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TMEM64 antibody (AA 40-118) (FITC)

TMEM64 Reactivity: Human Host: Rabbit Polyclonal FITC
Catalog No. ABIN7173259
  • Target See all TMEM64 products
    TMEM64 (Transmembrane Protein 64 (TMEM64))
    Binding Specificity
    AA 40-118
    Reactivity
    • 5
    • 1
    Human
    Host
    • 5
    Rabbit
    Clonality
    • 5
    Polyclonal
    Conjugate
    • 2
    • 1
    • 1
    • 1
    This TMEM64 antibody is conjugated to FITC
    Application
    Please inquire
    Cross-Reactivity
    Human
    Purification
    >95%, Protein G purified
    Immunogen
    Recombinant Human Transmembrane protein 64 protein (40-118AA)
    Isotype
    IgG
  • Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    TMEM64 (Transmembrane Protein 64 (TMEM64))
    Alternative Name
    TMEM64 (TMEM64 Products)
    Synonyms
    9630015D15Rik antibody, AI790744 antibody, AV300874 antibody, transmembrane protein 64 antibody, TMEM64 antibody, Tmem64 antibody
    Background

    Background: Positively regulates TNFSF11-induced osteoclast differentiation. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with SERCA2 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca (2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca (2+) signaling cascades that promote osteoclast differentiation and activation. Negatively regulates osteoblast differentiation and positively regulates adipocyte differentiation via modulation of the canonical Wnt signaling pathway. Mediates the switch in lineage commitment to osteogenesis rather than to adipogenesis in mesenchymal stem cells by negatively regulating the expression, activity and nuclear localization of CTNNB1.

    Aliases: TMEM64 antibody, TMM64_HUMAN antibody, Transmembrane protein 64 antibody

    UniProt
    Q6YI46
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