TRIB1 antibody (AA 3-91) (Biotin)
-
- Target See all TRIB1 Antibodies
- TRIB1 (Tribbles Homolog 1 (TRIB1))
-
Binding Specificity
- AA 3-91
-
Reactivity
- Human
-
Host
- Rabbit
-
Clonality
- Polyclonal
-
Conjugate
- This TRIB1 antibody is conjugated to Biotin
-
Application
- ELISA
- Cross-Reactivity
- Human
- Purification
- >95%, Protein G purified
- Immunogen
- Recombinant Human Tribbles homolog 1 protein (3-91AA)
- Isotype
- IgG
- Top Product
- Discover our top product TRIB1 Primary Antibody
-
-
- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Buffer
-
Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
- Target
- TRIB1 (Tribbles Homolog 1 (TRIB1))
- Alternative Name
- TRIB1 (TRIB1 Products)
- Synonyms
- TRIB1 antibody, c8fw antibody, gig2 antibody, skip1 antibody, trb1 antibody, tribbles antibody, C8FW antibody, GIG2 antibody, SKIP1 antibody, TRB1 antibody, A530090O15Rik antibody, TRB-1 antibody, Trb1 antibody, Gig2 antibody, tribbles pseudokinase 1 antibody, tribbles pseudokinase 1 L homeolog antibody, tribbles homolog 1 (Drosophila) antibody, TRIB1 antibody, trib1 antibody, trib1.L antibody, Trib1 antibody
- Background
-
Background: Adapter protein involved in protein degradation by interacting with RFWD2/COP1 ubiquitin ligase (PubMed:27041596). The RFWD2-binding motif is masked by autoinhibitory interactions with the protein kinase domain (PubMed:26455797). Serves to alter RFWD2 substrate specificity by directing the activity of RFWD2 toward CEBPA (PubMed:27041596). Binds selectively the recognition sequence of CEBPA (PubMed:26455797). Regulates myeloid cell differentiation by altering the expression of CEBPA in a RFWD2-dependent manner (By similarity). Controls macrophage, eosinophil and neutrophil differentiation via the COP1-binding domain (By similarity). Interacts with MAPK kinases and regulates activation of MAP kinases, but has no kinase activity (PubMed:15299019, PubMed:26455797).
Aliases: C8FW antibody, G-protein-coupled receptor-induced gene 2 protein antibody, GIG-2 antibody, GIG2 antibody, SKIP1 antibody, TRB-1 antibody, TRB1 antibody, Trib1 antibody, TRIB1_HUMAN antibody, Tribbles homolog 1 antibody
- UniProt
- Q96RU8
- Pathways
- Smooth Muscle Cell Migration
-