TRIM21 antibody (AA 1-470)
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- Target See all TRIM21 Antibodies
- TRIM21 (Tripartite Motif Containing 21 (TRIM21))
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Binding Specificity
- AA 1-470
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Reactivity
- Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This TRIM21 antibody is un-conjugated
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Application
- ELISA
- Cross-Reactivity
- Mouse
- Purification
- >95%, Protein G purified
- Immunogen
- Recombinant Mouse E3 ubiquitin-protein ligase TRIM21 protein (1-470AA)
- Isotype
- IgG
- Top Product
- Discover our top product TRIM21 Primary Antibody
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 - Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- TRIM21 (Tripartite Motif Containing 21 (TRIM21))
- Alternative Name
- Trim21 (TRIM21 Products)
- Synonyms
- RNF81 antibody, RO52 antibody, SSA antibody, SSA1 antibody, Ro52 antibody, Ssa1 antibody, tripartite motif containing 21 antibody, tripartite motif-containing 21 antibody, TRIM21 antibody, Trim21 antibody
- Background
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Background: E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B (\'Thr-187\' phosphorylated-form), thereby promoting its degradation by the proteasome. Monoubiquitinates IKBKB that will negatively regulates Tax-induced NF-kappa-B signaling. Negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3. Mediates the ubiquitin-mediated proteasomal degradation of IgG1 heavy chain, which is linked to the VCP-mediated ER-associated degradation (ERAD) pathway. Promotes IRF8 ubiquitination, which enhanced the ability of IRF8 to stimulate cytokine genes transcription in macrophages. Plays a role in the regulation of the cell cycle progression. Enhances the decapping activity of DCP2. Exists as a ribonucleoprotein particle present in all mammalian cells studied and composed of a single polypeptide and one of four small RNA molecules. At least two isoforms are present in nucleated and red blood cells, and tissue specific differences in RO/SSA proteins have been identified. The common feature of these proteins is their ability to bind HY RNAs.2.
Aliases: Trim21 antibody, Ro52 antibody, Ssa1 antibody, E3 ubiquitin-protein ligase TRIM21 antibody, EC 2.3.2.27 antibody, 52 kDa Ro protein antibody, 52 kDa ribonucleoprotein autoantigen Ro/SS-A antibody, RING-type E3 ubiquitin transferase TRIM21 antibody, Ro(SS-A) antibody, Sjoegren syndrome type A antigen antibody, SS-A antibody, Tripartite motif-containing protein 21 antibody
- UniProt
- Q62191
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