SUV39H1 antibody (AA 211-310) (HRP)

Catalog No. ABIN713570

Product Details anti-SUV39H1 Antibody (HRP)

Target: SUV39H1 (Suppressor of Variegation 3-9 Homolog 1 (Drosophila) (SUV39H1))

Binding Specificity: AA 211-310

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SUV39H1 antibody is conjugated to HRP

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Histone-lysine N-methyltransferase SUV39H1

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for SUV39H1

Target: SUV39H1 (Suppressor of Variegation 3-9 Homolog 1 (Drosophila) (SUV39H1))

Alternative Name: SUV39H1 (SUV39H1 Products)

Synonyms: H3-K9-HMTase 1 antibody, KMT1A antibody, MG44 antibody, SUV39H antibody, AI852103 antibody, AL022883 antibody, DXHXS7466e antibody, mIS6 antibody, RGD1565028 antibody, kmt1a antibody, suv39h antibody, fe02c04 antibody, suv39h1 antibody, wu:fe02c04 antibody, zgc:101027 antibody, fe47h06 antibody, wu:fb18a10 antibody, wu:fe47h06 antibody, zgc:136593 antibody, suppressor of variegation 3-9 homolog 1 antibody, suppressor of variegation 3-9 homolog 1 (Drosophila) antibody, suppressor of variegation 3-9 homolog 1 L homeolog antibody, suppressor of variegation 3-9 homolog 1a antibody, suppressor of variegation 3-9 homolog 1b antibody, SUV39H1 antibody, Suv39h1 antibody, suv39h1.L antibody, suv39h1a antibody, suv39h1b antibody

Background:

Synonyms: H3 K9 HMTase, H3 K9 HMTase1, H3-K9-HMTase 1, Histone H3 K9 methylation, Histone H3 Lys 9 methylation, Histone H3-K9 methyltransferase 1, Histone H3-K9 methyltransferase1, Histone lysine N methyltransferase H3 lysine 9 specic 1, Histone lysine N methyltransferase, H3 lysine 9 specic 1, Histone-lysine N-methyltransferase SUV39H1, KMT1 A, Lysine N methyltransferase 1A, Lysine N-methyltransferase 1A, MG44, mIS6, Position-effect variegation 3-9 homolog, Suvar3 9 homolog 1, Suvar3-9 homolog 1, Suppressor of variegation 3 9 homolog 1 Drosophila, Suppressor of variegation 3-9 homolog 1, SUV39 H1, SUV39H, SUV39H1, SUV91_HUMAN.

Background: SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as repression of MYOD1-stimulated differentiation, regulation of the control switch for exiting the cell cycle and entering differentiation, repression by the PML-RARA fusion protein, BMP-induced repression, repression of switch recombination to IgA and regulation of telomere length. Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus.

Gene ID: 6839