LIFR antibody (AA 45-188)

Catalog No. ABIN7193531

Product Details anti-LIFR Antibody

Target: LIFR (Leukemia Inhibitory Factor Receptor alpha (LIFR))

Binding Specificity: AA 45-188

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This LIFR antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Purification: purified

Immunogen: Purified recombinant fragment of human CD118 (AA: 45-188) expressed in E. coli.

Clone: 5D3G12

Isotype: IgG1

Application Details

Application Notes: WB:1:500 - 1:2000, FCM:1:200 - 1:400, ELISA:1:10000,

Restrictions: For Research Use only

Handling

Buffer: Purified antibody in PBS with 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: 4°C, -20°C for long term storage

Target Details for LIFR

Target: LIFR (Leukemia Inhibitory Factor Receptor alpha (LIFR))

Alternative Name: CD118 (LIFR Products)

Synonyms: A230075M04Rik antibody, AW061234 antibody, LIF antibody, CD118 antibody, LIF-R antibody, SJS2 antibody, STWS antibody, SWS antibody, leukemia inhibitory factor receptor antibody, LIF receptor alpha antibody, leukemia inhibitory factor receptor alpha antibody, Lifr antibody, LOC397451 antibody, LIFR antibody

Background:

Description: This gene encodes a protein that belongs to the type I cytokine receptor family. This protein combines with a high-affinity converter subunit, gp130, to form a receptor complex that mediates the action of the leukemia inhibitory factor, a polyfunctional cytokine that is involved in cellular differentiation, proliferation and survival in the adult and the embryo. Mutations in this gene cause Schwartz-Jampel syndrome type 2, a disease belonging to the group of the bent-bone dysplasias. A translocation that involves the promoter of this gene, t(5,8)(p13,q12) with the pleiomorphic adenoma gene 1, is associated with salivary gland pleiomorphic adenoma, a common type of benign epithelial tumor of the salivary gland. Multiple splice variants encoding two different isoforms have been found for this gene.

Aliases: LIFR, SWS, SJS2, STWS, LIF-R

Molecular Weight: 123.7 kDa

Gene ID: 3977

Pathways: JAK-STAT Signaling, Growth Factor Binding