NUP98 antibody (AA 1-218)

Catalog No. ABIN7193802

Product Details anti-NUP98 Antibody

Target: NUP98 (Nucleoporin 98kDa (NUP98))

Binding Specificity: AA 1-218

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This NUP98 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Flow Cytometry (FACS)

Purification: purified

Immunogen: Purified recombinant fragment of human NUP98 (AA: 1-218) expressed in E. coli.

Clone: 3G8C7

Isotype: IgG1

Application Details

Application Notes: WB:1:500 - 1:2000, ICC:1:200 - 1:1000, FCM:1:200 - 1:400, ELISA:1:10000,

Restrictions: For Research Use only

Handling

Buffer: Purified antibody in PBS with 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: 4°C, -20°C for long term storage

Target Details for NUP98

Target: NUP98 (Nucleoporin 98kDa (NUP98))

Alternative Name: NUP98 (NUP98 Products)

Synonyms: CG10198 antibody, CG10201 antibody, Dmel\\CG10198 antibody, Nup 96 antibody, Nup 98 antibody, Nup-98 antibody, Nup96 antibody, Nup98 antibody, Nup98-Nup96 antibody, Nup98/96 antibody, l(3)95BCd antibody, nup145 antibody, nup98-96 antibody, GB12688 antibody, NUP98 antibody, 4732457F17 antibody, AI849286 antibody, im:7151238 antibody, zgc:113968 antibody, zgc:63593 antibody, ADIR2 antibody, NUP196 antibody, NUP96 antibody, Nucleoporin 98-96kD antibody, nuclear pore complex protein Nup98-Nup96 antibody, nucleoporin 98 antibody, nucleoporin 98kDa antibody, nucleoporin 98 L homeolog antibody, Nup98-96 antibody, LOC408335 antibody, NUP98 antibody, LOC587580 antibody, Nup98 antibody, nup98 antibody, nup98.L antibody

Background:

Description: Nuclear pore complexes (NPCs) regulate the transport of macromolecules between the nucleus and cytoplasm, and are composed of many polypeptide subunits, many of which belong to the nucleoporin family. This gene belongs to the nucleoporin gene family and encodes a 186 kDa precursor protein that undergoes autoproteolytic cleavage to generate a 98 kDa nucleoporin and 96 kDa nucleoporin. The 98 kDa nucleoporin contains a Gly-Leu-Phe-Gly (GLGF) repeat domain and participates in many cellular processes, including nuclear import, nuclear export, mitotic progression, and regulation of gene expression. The 96 kDa nucleoporin is a scaffold component of the NPC. Proteolytic cleavage is important for targeting of the proteins to the NPC. Translocations between this gene and many other partner genes have been observed in different leukemias. Rearrangements typically result in chimeras with the N-terminal GLGF domain of this gene to the C-terminus of the partner gene. Alternative splicing results in multiple transcript variants encoding different isoforms, at least two of which are proteolytically processed. Some variants lack the region that encodes the 96 kDa nucleoporin.

Aliases: ADIR2, NUP96, NUP196, Nup98-96

Molecular Weight: 197.5 kDa

Gene ID: 4928

Pathways: Stem Cell Maintenance, Protein targeting to Nucleus, SARS-CoV-2 Protein Interactome