Neuregulin 4 antibody (AA 11-60)

Catalog No. ABIN7230132

The Rabbit Polyclonal anti-Neuregulin 4 antibody is suitable to detect Neuregulin 4 in samples from Human and Mouse. It has been validated for WB and ELISA.

Quick Overview for Neuregulin 4 antibody (AA 11-60) (ABIN7230132)

Target: Neuregulin 4 (NRG4)

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Neuregulin 4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Neuregulin 4 Antibody

Binding Specificity: AA 11-60

Purpose: Rabbit Anti-NRG4 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of NRG4 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human NRG4 protein at AA range: 11-60

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for Neuregulin 4

Target: Neuregulin 4 (NRG4)

Alternative Name: NRG4

Background: Pro-neuregulin-4, membrane-bound isoform, Pro-NRG4NRG4 (Neuregulin 4) is a Protein Coding gene. Among its related pathways are RET signaling and Signaling by ERBB2. GO annotations related to this gene include receptor binding and growth factor activity. Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors (By similarity).

Molecular Weight: 12kD

Gene ID: 145957

UniProt: Q8WWG1

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway