This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011],IIAE7,Cell Intrinsic Innate Immunity Signaling Pathway,Cytokines,Cytokines_Interferons,Epigenetics & Nuclear Signaling,Immunology & Inflammation,Innate Immunity_TLR Signaling,Protein phosphorylation,Toll-like Receptor Signaling Pathway,Transcription Factors,IRF3