NF-kappaB2 antibody, lyt antibody, p49 antibody, p49/p100 antibody, p50B antibody, p52 antibody, nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100 antibody, Nfkb2 antibody
Background
This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013],CVID10,H2TF1,LYT-10,LYT10,NF-kB2,p100,p49/p100,p52,Apoptosis,Apoptosis_Inhibition of Apoptosis,B Cell Receptor Signaling Pathway,Cancer,Cell Biology & Developmental Biology,Death Receptor Signaling Pathway,Epigenetics & Nuclear Signaling,IL-6 Receptor Signaling Pathway,Immunology & Inflammation,NF-kB Signaling Pathway,Protein phosphorylation,Signal Transduction,T Cell Receptor Signaling Pathway,Transcription Factors,NFKB2