RANBP2 antibody

Catalog No. ABIN7269843

Product Details anti-RANBP2 Antibody

Target: RANBP2 (RAN Binding Protein 2 (RANBP2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RANBP2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Purpose: RANBP2 Rabbit pAb

Cross-Reactivity: Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant protein of human RANBP2.

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for RANBP2

Target: RANBP2 (RAN Binding Protein 2 (RANBP2))

Alternative Name: RANBP2 (RANBP2 Products)

Synonyms: ANE1 antibody, IIAE3 antibody, NUP358 antibody, TRP1 antibody, TRP2 antibody, A430087B05Rik antibody, AI256741 antibody, RGD1560047 antibody, RANBP2 antibody, ane1 antibody, nup358 antibody, trp1 antibody, trp2 antibody, RAN binding protein 2 antibody, E3 SUMO-protein ligase RanBP2 antibody, RANBP2 antibody, Ranbp2 antibody, LOC474539 antibody, ranbp2 antibody, LOC100511376 antibody

Background: RAN is a small GTP-binding protein of the RAS superfamily that is associated with the nuclear membrane and is thought to control a variety of cellular functions through its interactions with other proteins. This gene encodes a very large RAN-binding protein that immunolocalizes to the nuclear pore complex. The protein is a giant scaffold and mosaic cyclophilin-related nucleoporin implicated in the Ran-GTPase cycle. The encoded protein directly interacts with the E2 enzyme UBC9 and strongly enhances SUMO1 transfer from UBC9 to the SUMO1 target SP100. These findings place sumoylation at the cytoplasmic filaments of the nuclear pore complex and suggest that, for some substrates, modification and nuclear import are linked events. This gene is partially duplicated in a gene cluster that lies in a hot spot for recombination on chromosome 2q. [provided by RefSeq, Jul 2008],ADANE, ANE1, IIAE3, NUP358, TRP1, TRP2,Cell Biology & Developmental Biology,Cell Cycle,Epigenetics & Nuclear Signaling,Signal Transduction,Ubiquitin,RANBP2

Gene ID: 5903

UniProt: P49792

Pathways: Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus