TTLL12 antibody

Catalog No. ABIN7271032

Product Details anti-TTLL12 Antibody

Target: TTLL12 (Tubulin tyrosine Ligase-Like Family, Member 12 (TTLL12))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TTLL12 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Purpose: [KO Validated] TTLL12 Rabbit pAb

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Grade: KO Validated

Immunogen: Recombinant protein of human TTLL12.

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for TTLL12

Target: TTLL12 (Tubulin tyrosine Ligase-Like Family, Member 12 (TTLL12))

Alternative Name: TTLL12 (TTLL12 Products)

Synonyms: zgc:55343 antibody, dJ526I14.2 antibody, RGD1305319 antibody, BC055368 antibody, D430005B17 antibody, tubulin tyrosine ligase-like family, member 12 antibody, tubulin tyrosine ligase like 12 antibody, Tubulin--tyrosine ligase-like protein 12 antibody, ttll12 antibody, TTLL12 antibody, ttll-12 antibody, Ttll12 antibody

Background: Negatively regulates post-translational modifications of tubulin, including detyrosination of the C-terminus and polyglutamylation of glutamate residues. Also, indirectly promotes histone H4 trimethylation at 'Lys-20' (H4K20me3. Probably by controlling tubulin and/or histone H4 post-translational modifications, plays a role in mitosis and in maintaining chromosome number stability. During RNA virus-mediated infection, acts as a negative regulator of the DDX58/RIG-I pathway by preventing MAVS binding to TBK1 and IKBKE.,TTLL12,dJ526I14.2,Signal Transduction,Cell Biology & Developmental Biology,Cytoskeleton,Microtubules,TTLL12

Molecular Weight: 74kDa

Gene ID: 23170

UniProt: Q14166