TNFRSF18 antibody (AA 26-255)

Catalog No. ABIN7271067

Product Details anti-TNFRSF18 Antibody

Target: TNFRSF18 (Tumor Necrosis Factor Receptor Superfamily, Member 18 (TNFRSF18))

Binding Specificity: AA 26-255

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TNFRSF18 antibody is un-conjugated

Application: Western Blotting (WB)

Purpose: GITR/TNFRSF18 Rabbit pAb

Sequence: QRPTGGPGCG PGRLLLGTGT DARCCRVHTT RCCRDYPGEE CCSEWDCMCV QPEFHCGDPC CTTCRHHPCP PGQGVQSQGK FSFGFQCIDC ASGTFSGGHE GHCKPWTDCC WRCRRRPKTP EAASSPRKSG ASDRQRRRGG WETCGCEPGR PPGPPTAASP SPGAPQAAGA LRSALGRALL PWQQKWVQEG GSDQRPGPCS SAAAAGPCRR ERETQSWPPS SLAGPDGVGS

Cross-Reactivity: Mouse

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 26-255 of human GITR/TNFRSF18 (NP_683699.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for TNFRSF18

Target: TNFRSF18 (Tumor Necrosis Factor Receptor Superfamily, Member 18 (TNFRSF18))

Alternative Name: TNFRSF18 (TNFRSF18 Products)

Synonyms: GITR antibody, TNFRSF18 antibody, AITR antibody, Gitr antibody, CD357 antibody, GITR-D antibody, TNF receptor superfamily member 18 antibody, tumor necrosis factor receptor superfamily, member 18 antibody, TNFRSF18 antibody, Tnfrsf18 antibody

Background: This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.,TNFRSF18,AITR,CD357,GITR,GITR-D,Cancer,Signal Transduction,Cell Biology & Developmental Biology,Growth factor,TNF,Immunology & Inflammation,CD markers,Cytokines,TNF,NF-kB Signaling Pathway,Cell Intrinsic Innate Immunity Signaling Pathway,TNFRSF18

Molecular Weight: 25kDa/26kDa

Gene ID: 8784

UniProt: Q9Y5U5

Pathways: Cancer Immune Checkpoints